Examples of our services
• Vasculature and Blood Flow
Detailed 4D (3D + Time) measurement of meningeal and cortical vessels, including arterioles and venules, and flow rate quantification
• Angiogenesis and Lymphangiogenesis
Quantitative longitudinal analysis of blood and lymphatic vessel morphology in disease models of e.g. cancer, trauma and repair
• Blood-Brain Barrier Integrity
Quantitative measurement of BBB permeability by systemic injection of several dextran dyes of different molecular weight followed by multicolour time-lapse imaging
• Neuronal and Glial Morphology
4D monitoring of disease- or drug-induced changes in neuronal dendritic spines or fine processes of astrocytes and microglia
• Intracellular Calcium Signalling
Calcium imaging in individual neurons and/or astrocytes as a sensitive functional readout of brain circuits under a variety of pathophysiological conditions and in response to drug action
• Mitochondrial Signalling
Imaging of shape, motility and/or membrane potential of mitochondria e.g. in stroke, cancer or neurodegeneration models, and in the course of drug action
• PK of Tagged Biologics
Kinetic quantitative imaging of large molecule's permeation through BBB, their accumulation in tissue (e.g. brain parenchyma) and subsequent clearance from tissue and circulation
• Ischemic and Hemorrhagic Stroke Models
Longitudinal analysis of vasculature, blood flow and brain cells' moprho-fucntional changes during onset of and recovery from experimental stroke induced by Rose Bengal photosensitization, direct laser-induced thrombosis or artery occlusion
• Traumatic Brain Injury (TBI)
Longitudinal imaging of moprho-fucntional changes in cortical cells during recovery from TBI induced either mechanically (e.g., needle insertion or concussion) or optically (laser-induced neuropil lesion)
• Chronic Pain Mechanisms
Multiparametric quantitative analysis of key elements of neuropathic/inflammatory pain, e.g. synaptic turnover, axon sprouting, microglia activation and migration, plasma extravasation and cortical spreading depression
• Single Cell Tracking
Longitudinal monitoring of individual cells (e.g., immune, cancer or stem cells), quantification of their velocities and trajectories along with changes in their morphology
• Skin Layers and Collagen Structure
Quantitative longitudinal analysis of intact skin of living animals as well as humans in pathology (e.g. skin cancers, photoaging, dermatological conditions) or during transdermal drug delivery