Mobile HomeCage References

180+ labs worldwide use the Mobile HomeCage devices for research in awake head-fixed mice. On this page, we have compiled the Mobile HomeCage references. They include publications, links to educational webinars, video testimonials, and a list of research institutions that use our equipment. Use the menu below to navigate to a specific category:


Jafarian, A., Wykes, R. C. (Front. Comput. Neurosci., 2022). Impact of DC-coupled electrophysiological recordings for translational neuroscience: case study of tracking neural dynamics in rodent models of seizures.

Redman et al. (eLife, 2022). Long-term transverse imaging of the hippocampus with glass micro-periscopes

Kucharz et al. (Pharmaceutical Research, 2022). Shedding Light on the Blood–Brain Barrier Transport with Two-Photon Microscopy In Vivo.

Karalis, N., Sirota, A. (Nature Communications 13, 467, 2022). Breathing coordinates cortico-hippocampal dynamics in mice during offline states.

Kucharz et al. (Nature Communications, 2021). Post-capillary venules are the key locus for transcytosis-mediated brain delivery of therapeutic nanoparticles

Calia et al. (Nature Nanotechnology, 2021). Full-bandwidth electrophysiology of seizures and epileptiform activity enabled by flexible graphene microtransistor depth neural probes.

Dooley et al. (Current Biology, 2021). Movements during sleep reveal the developmental emergence of a cerebellar-dependent internal model in motor thalamus.

Lu, J., Tjia, M., Mullen, B. et al. (Mol Psychiatry, 2021). An analog of psychedelics restores functional neural circuits disrupted by unpredictable stress.

O. Ivashkina, A. Gruzdeva, M. Roshchina, K. Toropova, K. Anokhin (Int. J. Mol. Sci., 2021). Imaging of C-fos Activity in Neurons of the Mouse Parietal Association Cortex during Acquisition and Retrieval of Associative Fear Memory.

R. Padmashri, K. Tyner, A. Dunaevsky (J. Vis .Exp., 2021). Implantation of a Cranial Window for Repeated In Vivo Imaging in Awake Mice.

S. H. Bitzenhofer, J. A. Pöpplau, M. Chini, A. Marquardt, I. L. Hanganu-Opatz (Neuron,  2021). A transient developmental increase in prefrontal activity alters network maturation and causes cognitive dysfunction in adult mice.

Polina A. Egorova, Aleksandra V. Gavrilova, Ilya B. Bezprozvanny (Cell Calcium, 2021) In vivo analysis of the spontaneous firing of cerebellar Purkinje cells in awake transgenic mice that model spinocerebellar ataxia type 2.

W.Yang, M.Chini, J.A. Pöpplau, A.Formozov, A. Dieter, P. Piechocinski, C. Rais, F. Morellini,
O. Sporns, I. L. Hanganu-Opatz, J. S. Wiegert (PLoS Biology, 2021) Anesthetics fragment hippocampal network activity, alter spine dynamics, and affect memory consolidation.

E.Masvidal-Codina, T. M. Smith, D.Rathore, Y. Gao, X. Illa, E. Prats-Alfonso, E. Del Corro, A.Bonaccini Calia, G. Rius, I. Martin-Fernandez, C. Guger, P. Reitner, R. Villa, J. A. Garrido, A. Guimerà-Brunet, R.C. Wykes (Journal of Neural Engineering, 2021) Characterization of optogenetically-induced cortical spreading depression in awake mice using graphene micro-transistor arrays.

A.L.Keyesa, Y. Kimb, P. J.Bosch, Y.M.Usachev, G.M. Aldridge (Cell Calcium, 2021) Stay or Go? Neuronal activity in medial frontal cortex during a voluntary tactile preference task in head-fixed mice.

A. Bertolo, M. Nouhoum, S. Cazzanelli, J. Ferrier, JC. Mariani, A. Kliewer, B. Belliard, BF. Osmanski, T. Deffieux, S. Pezet, Z. Lenkei, M. Tanter (J. Vis. Exp, 2021) Whole-brain 3D activation and functional connectivity mapping in mice using transcranial functional ultrasound imaging.

M. A. Go, J. Rogers, G. Gava, C. Davey, s. Prado, Y. Liu, S. Schultz (Frontiers in Cellular Neuroscience, 2021) Place cells in head-fixed mice navigating a floating real-world environment.

A. Rakymzhan, Y. Li, P. Tang, R. K. Wang (Journal of Neuroscience Methods, 2021) Differences in cerebral blood vasculature and flow in awake and anesthetized mouse cortex revealed by quantitative optical coherence tomography angiography.

Lee HS, Han JH. (J Vis Exp., 2020) Successful In vivo Calcium Imaging with a Head-Mount Miniaturized Microscope in the Amygdala of a Freely Behaving Mouse

A.M. Ingiosi, C.R. Hayworth, D.O. Harvey et al. (Current Biology, 2020) A role for astroglial calcium in mammalian sleep and sleep regulation.

A.D. Umpierre, L.L Bystrom, Y. Ying, Y. U. Liu, G.Worrell, L.J. Wu (eLife, 2020) Microglial calcium signaling is attuned to neuronal activity in awake mice.

K. Juczewski, J. Koussa, A. J. Kesner, J. O. Lee, D. M. Lovinger (Scientific Reports, 2020) Stress and behavioral correlates in the head-fixed method: stress measurements, habituation dynamics, locomotion, and motor-skill learning in mice.

J. Ferrier, E. Tiran, T. Deffieux, M. Tanter, Z. Lenkei (PNAS, 2020) Functional imaging evidence for task-induced deactivation and disconnection of a major default mode network hub in the mouse brain.

Y. Li, A. Rakymzhan, P. Tang, R.K. Wang (Biomedical Optics Express, 2020) Procedure and protocols for optical imaging of cerebral blood flow and hemodynamics in awake mice.

A.D. Hogan-Cann, P. Lu, C. M. Anderson (PNAS, 2019) Endothelial NMDA receptors mediate activity-dependent brain hemodynamic responses in mice.

W. Sun, K. Suzuki, D. Toptunov, S. Stoyanov, M. Yuzaki, L. Khiroug, A. Dityatev (Frontiers in Neuroscience,2019) In vivo Two-Photon Imaging of Anesthesia-Specific Alterations in Microglial Surveillance and Photodamage-Directed Motility in Mouse Cortex.

E. Pryazhnikov et al. (Scientific Reports, 2018) Longitudinal two-photon imaging in somatosensory cortex of behaving mice reveals dendritic spine formation enhancement by subchronic administration of low-dose ketamine.

H. Antila et al. (Scientific Reports, 2017)  Isoflurane produces antidepressant effects and induces TrkB signaling in rodents.

M. Kislin et al. (Journal of Visual Experiments, 2014)  Flat-floored air-lifted platform: a new method for combining behavior with microscopy or electrophysiology on awake freely moving rodents.


Haruwaka, K., Ying, Y., Liang, Y., Umpierre, A.D., Yi, M.H., Kremen, V., Chen, T., Xie, T., Dong, H., Worrell, G. and Wu, L.J. (2022) Microglial process dynamics enhance neuronal activity by shielding GABAergic synaptic inputs.

Fiore F., Dereddi R. R., Alhalaseh K., Coban I., Harb A., Agarwal A. (2022) Norepinephrine regulates Ca2+ signals and fate of oligodendrocyte progenitor cells in the cortex.

Gómez L. J., Dooley J. C., Blumberg, M. S. (2022) Activity in the developing prefrontal cortex is shaped by sleep and sensory experience.

Tessier, M., Garcia, S. M., Goubert, E., Tian, Li., Molinari, F., Blasco, E., Laurin, J., Guillemot, F., Hübner, C., Pellegrino, C., Rivera, C. (2022). Bumetanide increases microglia-interneuron contact following traumatic brain injury.

Zong, F. J., Zhang, X. T., Zhang, Y., Min, X., Liu, Y., & He, K. W. (2022) Mechanism and consequence of daily modulation of cortical parvalbumin-positive inhibitory neurons.

Shi, L., Rodriguez-Contreras, A. (2022). The general anesthetic isoflurane inhibits calcium activity in cerebrovascular endothelial cells and disrupts vascular tone.

Sit, K., Goard, M. (2022). Coregistration of heading to visual cues in retrosplenial cortex.

Krogsgaard, A., Sperling, L., Dahlqvist, M., Thomsen, K., Vydmantaite, G., Lauritzen, M., & Lind, B. L. (2022). Astrocytic Ca2+ signals partake in inhibitory neurovascular coupling in a brain state-dependent manner.

A. Virenque, R. Balin, F. M. Noe (2021) Dorsal skull meningeal lymphatic vessels drain blood-solutes after intracerebral hemorrhage.

Video articles in the Journal of Visualized Experiments (Jove)

Bertolo, A., et al. (2021) Whole-Brain 3D Activation and Functional Connectivity Mapping in Mice using Transcranial Functional Ultrasound Imaging.

Kislin, M., et al. (2014) Flat-floored Air-lifted Platform: A New Method for Combining Behavior with Microscopy or Electrophysiology on Awake Freely Moving Rodents.

How to cite us

We would appreciate you mentioning our equipment when you publish: please refer to our equipment as the Mobile HomeCage (or HeadFix, if you are using head fixation part only) and to our company as Neurotar. Thank you!

Educational webinars

Coming soon! Neurovascular Coupling: Novel Insights from Studies in Awake Head-Fixed and Anesthetized Mice. Presenters: Barbara Lind (Assistant Professor at the University of Copenhagen) and Adrián Rodríguez-Contreras (Associate Professor at Northwestern University). November 3, 2022. Click on the image below to register on the InsideScientific platform.

Sensorimotor Network Development During Early Postnatal Life in the Awake and Sleeping Brain. Presenters: Anna Cavaccini (Theofanis Karayannis lab, University of Zurich), James Dooley (Mark Blumberg lab, University of Iowa). September 2, 2021.

Hippocampal Neural Circuits in Awake Head-Fixed Mice Navigating a Real-World Environment. Presenting labs: Simon Schultz (Imperial College London), Michael Goard (University of California at Santa Barbara). February 18, 2021.

Studying Epilepsy in Awake Head-Fixed Mice Using Microscopy, Electrophysiology, and Optogenetics. Presenting labs: Longjun Wu lab (Mayo Clinic, USA), Rob Wykes lab (UCL, UK). October 8, 2020

Functional Ultrasound (fUS) Imaging in the Brain of Awake Behaving Mice. June 30, 2020.

Place Cell Mapping and Stress Monitoring in Head-Fixed Mice Navigating an Air-Lifted Homecage. August 23, 2019

Single-Cell Electrophysiology and 2-Photon Imaging in Awake Mice with 2D-Locomotion Tracking. February 6, 2019

Making Optical and Electrophysiological Measurements in the Brain of Head-Fixed, Freely-Moving Rodents. March 25, 2015


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